0002251 Aganglionic megacolon

synonym Congenital megacolon Hirschsprung disease Hirschsprung megacolon Megacolon Enlarged colon lacking nerve cells

comment Aganglionic megacolon is characterized by congenital absence of intrinsic ganglion cells in the myenteric (Auerbach) and submucosal (Meissner) plexuses of the gastrointestinal tract.