0003524 Decreased methionine synthase activity

synonym Decreased activity of methionine synthase Methionine synthase deficiency Methionine synthetase activity decreased Reduced methionine synthase activity

comment Cobalamin-dependent methionine synthase catalyzes the transfer of a methyl group from N5-methyltetrahydrofolate to homocysteine, producing tetrahydrofolate and methionine, i.e., (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.